The Centers for Disease Control recommends that adults get Moderna's COVID-19 vaccine following full approval from the Food and Drug Administration.
The FDA licensed the shots this week, so a CDC advisory committee and the agency itself were called on to do an additional review.
The panel heard summaries of medical studies that showed the vaccine is working against the coronavirus and there is no evidence of new safety concerns.
They voted unanimously to recommend the vaccine.
CDC Director Rochelle Walkensky endorsed the recommendation.
"We now have another fully approved COVID-19 vaccine," Walensky said in a statement. "If you have been waiting for approval before getting vaccinated, now is the time to join the nearly 212 million Americans who have already completed their primary series."
Friday's endorsement is likely to have little effect on the vaccination of adults in the U.S. Moderna's vaccine was operating under emergency use authorization which allowed millions of people to get the shot.
However, Walensky also encouraged people to get their booster shots.
"CDC continues to recommend that people remain up to date on their COVID-19 vaccines, including getting a booster shot when eligible," she said.